Maom Lab @ UMich

We a computational pharmacology group in the Department of Computational Medicine and Bioinformatics at the Univerersity of Michigan in Ann Arbor, Michigan. We use computational and statistical modeling to develop chemical probes.

In science models are used to simulate the behavior of intractable systems that we want to understand. For example, cell-culture may be use to model an organisms response to drugs.

model building paradigm

In our group, we do two types of modeling. First we use molecular simulations and deep neural networks to represent how molecules and chemicals interact. While computational models are can be quite realistic, often they are intractable and difficult to compare with biochemical and phenotypic measurements. So, second we use statistical models to facilitate summarizing experimental data and making inferences.

We are fortunate to collaborate with a range of exciting experimental labs, where we work closely with them to analyze the data and plan new experiments.

News

Apr 14 2022

We will be hosting the first Bayesetta workshop for Bayesian Statistical Modeling Workshop for Rosetta-based Modeling June 27-28th.

Apr 5 2022

Madeline Martin has been accepted into the University of Oregon’s Bioengineering PhD program!

Aug 19 2021

Dr. Kalinin’s first-author paper Valproic acid-induced changes of 4D nuclear morphology in astrocyte cells (Kalinin, et al., Mol. Biol. Cell, 2021) has been published in Molecular Biology of the Cell. In collaboration with Athey, Dinov, Xiang WAN (CUHK-CZ), and Sexton Lab Labs – Congrats to all!

Nov 10 2021

Dr. O’Meara presents Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 at the B/D-HPP Webinar on “SARS-CoV-2 through the lens of proteomics”

Nov 11 2021

Our new paper “Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets” (Fu, et al., Nat. Comm, 2021) has come out in Nature Communications. In collaboration with the Cowen, Myers, T. O’Meara Labs – Contrats to all!

Nov 12 2021

Dr. O’Meara is quoted in Investigating Antidepressants’ Surprising Effect on COVID Deaths in the Scientific American article about the mechanism of fluvoxamien for COVID-19.

Nov 23 2021

Dr. Kalinin presents Shape modeling for 4D nuclear morphology analysis in VPA-treated astrocyte cells at the 2021 Crick BioImage Analysis Symposium.

Jan 27 2022

Applications for the Rosetta Postbac Program due Feb 1. Apply today!

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